In this case, the obvious presence of SCC precluded those entities except carcinosarcoma. Case presentation A 75-year-old man presented with fever Apr 27, 2023 · Synovial sarcoma. It is associated Jan 25, 2017 · Types of Spindle Cell Sarcoma. I would be cancer free 2 years on 3/15/15. 1. The diagnosis of SCM is challenging, as SCM may occur anywhere on the body and frequently mimics amelanotic lesions, including scarring and inflammation (2–4). Fibrosarcomas and spindle cell tumors originate from the connective tissue of, or beneath, the skin. There are a lot of factors that could greatly affect the person’s chance of survival such as the type of sarcoma, location of the tumor, age of the patient, and the type of treatment received by the patient. Treatment Options for Spindle Cell Sarcoma. After five weeks of radiation to the leg, a ct scan of the chest showed mets to both lungs, then after six cycles of white lightening and red devil he had two VATS procedures in May of 2014 to remove the nodules. Sep 19, 2022 · Background It has been reported that hepatocellular carcinoma (HCC) with spindle cell tumor accounts for 1. . Synovial sarcoma is the most well-established 'translocation-associated sarcoma,' and several molecular techniques are used to determine this translocation. It is composed of squamous cell carcinoma (SCC), either in situ and/or in invasive form, and a malignant spindle cell component with a mesenchymal appearance, but of epithelial origin []. In this report, we describe a case of resection of a primary spindle cell tumor of the liver that was difficult to diagnose. This study aimed to review the clinical and pathological characteristics for diagnosis and prognosis. Feb 2, 2023 · Here are some survival statistics for spindle cell sarcoma: 75% of people diagnosed with spindle cell sarcoma in England survive their disease for one year or more (2013-2017). Jun 6, 2022 · The soft tissue sarcoma staging process involves several values, including: T (tumor): describes the size of the original tumor. Alternatively, a fine needle aspirate may be performed, especially if the tumor is filled with liquid. Genetic counseling may be right for you. Was diagnosis with High Grade Retroperitoneal (Iliopsoas) Sarcoma. ). 8% at 1-year and 70. However, soft tissue malignancies are further subclassified in approximately 70 subtypes, each characterized by a distinct morphology, that often translates into a specific clinical behaviour as well as into specific therapeutic approaches. The grade of a sarcoma helps predict how rapidly it will grow and spread. RMS is the most common soft tissue sarcoma diagnosed in children; only 1% of these cancers are found in adults. Histology of the solid tumor showed spindle-shaped cells arranged in a storiform pattern and accompanied by fibrous tissue (Fig. Jun 4, 2008 · Certain tumors such as biphasic synovial sarcomas have characteristic aspects, but most do not. Nov 8, 2015 · Synovial sarcoma (SS) is an aggressive spindle cell tumor that accounts for approximately 10% of all STSs. Feb 14, 2019 · In most cases, after surgery, chemotherapy and/or radiation may be required. I had a tube sewn in my leg to drain the fluid. Jun 20, 2024 · The five-year survival rate for synovial sarcoma is 50% to 60%. Synovial sarcoma begins as a growth of cells that can multiply quickly and destroy healthy tissue. Disclosure: All authors demonstrate that each one has contributed to the work and takes the responsibility for the manuscript. Jul 22, 2021 · Depending on the tumor cell appearance after hematoxylin and eosin staining, three morphological types have been identified: spindle cell type, epithelioid type and mixed type [43,44]. Primary spindle cell sarcoma (SCS) is an extremely rare entity and one of the least reported tumor 2. 5%. For these tumors, radiation with or without chemotherapy (chemo) may be given before surgery. When viewed under a microscope, the cancerous cells appear long and narrow (spindle-shaped). Primary spindle cell sarcoma (SCS) is an extremely rare entity and one of the least May 19, 2020 · Background Primary cardiac tumors are extremely rare. The anatomic location of the tumour, infiltration into vital structures and difficult access provides a surgical challenge for resection of the lesion and recon … Spindle cell sarcoma in muscle tissue. Mesenchymal stem cells are the most likely origin of the tumor, instead of histiocytes as previously thought. The fourth edition of the World Health Organization (WHO) classification of tumors of soft tissue and bone published in 2013 updated the older 2002 classification, introduced several changes in soft-tissue tumor classification, and described new genetic and molecular data for the tumors [5, 6]. Another study had reported the possible detrimental effects of radiotherapy when added to surgery in terms of survival . Due to its rarity, only a few cases have been described in medical literature [ 5 ]. Feb 12, 2024 · Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma that is believed to originate from primitive mesenchymal cells that typically differentiate into skeletal tissue. Doctors know this cancer begins when a cell develops changes in its DNA. Spindle-cell carcinoma has characteristics of both carcinoma and sarcoma. Most malignant spindle-cell neoplasms are called sarcomas. Synovial sarcoma is a rare type of cancer that tends to occur near large joints, mainly the knees. I did 3 rounds of chemo (dox and fofs), then 5 weeks of radiation and then got the tumor removed. Nov 18, 2015 · Watson et al investigated 30 cases of SpCC and found that EGFR was expressed in 21/30 (70%) cases, including in the squamous component in 18/19 (95%) and the spindle cell component in only 12/30 (40%). Due to the low incidence, there is a paucity of data on the clinical presentation, diagnostic techniques and standard treatment of the disease. Oct 22, 2014 · I posted over a year ago-- I spoke of my husband who was dx in early Sept 2013 with spindle cell sarcoma. Social Security. Include one or two photos of the sarcoma patient/survivor. If you have been diagnosed with sarcoma and are unable to work and earn a living, you may be eligible for Social Security Disability Benefits. Unfortunately, the overall survival rate is less than 5 years since most spindle cell sarcoma cases are diagnosed in advanced stages [11,12]. Today the surgeon told me it was a malignant spindle cell tumor but only about 2. Aug 1, 2018 · Introduction. These tumors range in Sep 16, 2016 · Abbreviations: MST = median survival time, OS = overall survival, SCC = squamous cell carcinoma, SpCC = spindle cell carcinoma. Crago, about 50% of sarcoma survivors with a local sarcoma recurrence discover it themselves. Methods We included all patients treated for LGMS at our institution Complete excision of the mass displayed a yellowish spherical tumor with a well-circumscribed appearance measuring 98 x 95 mm. The data of patients with SCS between 2004 and 2020 were … asking for treament options spindle cell sarcoma Best wishes and good luck to everyone here. Background: Spindle cell carcinoma (SpCC) is a rare tumor type with poor prognosis, and standard treatment modalities are not available yet. Apr 27, 2023 · Gastrointestinal stromal tumor (GIST) A gastrointestinal stromal tumor (GIST) is a type of cancer that begins in the digestive system. 24 mm 2 in area). That said, according to Dr. For example, angiosarcoma begins in cells in the lining of blood vessels, while liposarcoma starts in fat cells. We report the cases of two patients with primary cardiac sarcoma treated Aug 14, 2023 · Soft tissue sarcomas (STS) are a group of more than 60 different neoplasms that can originate from any location throughout the human body and affect individuals at the extremes of age. I have a quite large tumor in my hip/thigh area. 7 in Holland (), 11 in Iceland and 6. 7:1 and a median age at diagnosis of 62 years [ 1 ]. Apr 15, 2023 · (D) Center of the mass showing high-grade sarcoma composed of pleomorphic spindle cells and numerous tumor giant cells with central necrosis (H&E stain, x10). Spindle Cell Sarcomas. Genetic predisposition is one factor, but it also may be caused by Jul 17, 2018 · 2. But sarcoma can be hard to detect through symptoms. 8% of all HCCs, but spindle cell tumors that do not show an obvious conventional HCC are extremely rare. Jan 5, 2021 · Background Actuarial survival based on the Kaplan–Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Pleomorphic Spindle Cell Sarcoma I had a large Pleomorphic Spindle Cell Sarcoma removed from my right rib cage over two years ago followed by two more surgeries and two week-long chemos. Spindle cell sarcoma gets its name from the way it is Spindle cell carcinoma (SCC) is a rare pulmonary malignancy, accounting for only 0. Jan 10, 2020 · Leiomyosarcoma, a common subtype of soft tissue sarcoma (STS), accounts for up to 10% to 20% of all sarcomas. When spindle cell sarcoma arises in the heart, the differential diagnosis includes angiosarcoma or synovial sarcoma. Oct 23, 2023 · Spindle-cell neoplasm is considered a general term because it includes many different types of benign (non-cancerous) and malignant (cancerous) growths. [1] It can affect soft tissues, bones, retroperitoneum, and metastasize to several organs. There was inflammatory cell infiltration, most of which were monocytes. However, these tumors can also arise in other types of tissue and any anatomic area. Primary end-point: progression-free survival (PFS) at Jul 21, 2014 · Introduction. Jun 7, 2021 · Sarcoma prognosis is unique to the individual's medical history, type of sarcoma, stage of cancer at diagnosis, and response to treatment. May 25, 2020 · e21048 Background: Spindle cell lung cancer (SpCC) is a rare type of NSCLC which portends a poor prognosis. The tumor is diverse in appearance and several different cell lines produce tumors of similar appearance. In October of 2015 he went for a check up and was told there was a mass on his kidney over the next few months he was going back and forth to the hospital for different checks. There is no definite known cause for this type of tumour, but it can sometimes occur as a result of previous radiotherapy Pheomorphic Spindle Cell Sarcoma Survivor. Stage 4 Spindle cell sarcoma. Due to the fact that the spindle cell sarcomas don’t grow at a speedy rate Jun 6, 2017 · The respiratory system was mostly affected tumor site (35%). ; For those coded as malignant (excluding intermediate behaviour), survival was 83. However, no studies have reported on the surgical treatment method and its long-term outcomes. Did 7 rounds of Doxirubin, Ifosfimideand Mesna, then 25 treatments of radation. However, large-scale studies on this topic are sparse. About 70% of people with rhabdomyosarcoma are alive five years after diagnosis. Learn more about soft tissue sarcoma: Soft tissue sarcoma symptoms; Soft tissue sarcoma diagnosis; Soft tissue sarcoma treatment; Some cases of soft tissue sarcoma can be passed down from one generation to the next. We highly appreciate the following as we’ve found newly diagnosed patients are very interested in reading stories of people with similar diagnosis. You may be your own best sarcoma screening method. There is no clear evidence that radiation therapy or chemotherapy offers an advantage in terms of survival. It is best to seek care at a cancer center that has experience treating people with sarcoma. It is in his lower left calf. Although the tumor is principally located in the lower extremities, primary SS at other sites (including the head and neck, hands, retroperitoneum, digestive system and mediastinum) have been reported[64-66]. , adipocytic, fibroblastic and myofibroblastic, vascular, smooth and skeletal muscle, peripheral nerve sheath malignant tumors) and sub-types (e. Hello. Mar 22, 2018 · Spindle cell neoplasm are diverse in nature by means of clinicopathologic and tumor biological heterogeneity 1. The chemo caused tissue death of the tumor and the radiation further reduced it. My story began in Spring 2013 after completing 20+ years of income tax seasonal work for Mayo Clinic’s Office of Staff Services in Rochester, Minnesota. Spindle cell carcinoma represents a rare variant of squamous cell carcinoma, characterized by spindled tumor cells that simulate a sarcoma but are epithelial in nature. 5cm big. What is Spindle Cell Sarcoma? Spindle cell sarcoma is an extremely rare bone cancer. Sep 24, 2022 · Background DICER1-associated central nervous system sarcoma (DCS) without evidence of other cancer-related syndromes is rare. There are many types of soft tissue sarcoma. 2C and D). Learn how sarcoma survival rate and treatment varies by stage, including survival rate for stage 4 sarcoma (sarcoma with metastasis). Oct 10, 2022 · The tumor had not extended beyond the splenic capsule and the surgical margin was negative. [1] Nov 28, 2011 · spindle cell sarcoma Hello, Keeping positive seems to be the one thing really helping! i am 33 years old and was just diagnosed with spindle cell sarcoma. Figure 2 shows the histological aspects of the spindle cell type in GISTs, and Figure 3 presents the histological aspects of the epithelioid type in GISTs. The prognosis is poor with a mean survival of 3 months to 1 year, even with complete radical resection. Some types of soft tissue sarcoma include: Angiosarcoma. 3% of all lung cancers. Spindle cell RMS are rare tumors forming only 5%–10% of all RMS cases and are now considered a distinct entity, separate but related to embryonal RMS. Optimal treatment is to obtain complete surgical clearance of the tumour. 3 months after her surgery she had her first CT scan and the result shows that there are new lesions appeared on her right lung and pancreas. My mom was diagnosed with Spindle cell Sarcoma in the upper part of her left lung on Dec 2009 and had a surgery to remove the whloe left part on feb 2010. Medical science has been discovered four different variations in the spindle cell sarcoma affecting Apr 10, 2020 · Epithelioid sarcoma: Giant cell tumor of soft tissues: Alveolar soft-part sarcoma: Smooth muscle tumors: Clear cell sarcoma of soft tissue: Leiomyosarcoma: Extraskeletal myxoid chondrosarcoma: Pericytic (perivascular) tumors: Extraskeletal Ewing sarcoma: Malignant glomus tumor: Desmoplastic small round cell tumor: Skeletal muscle tumors Spindle-cell carcinoma is named after the way its cells look under a microscope. The brain is a rare metastatic site in patients with sarcoma and the available information is relatively limited. Spindle cell sarcoma. [1] The etiology and risk There is evidence that patients with extremity spindle cell sarcoma and extraskeletal osteosarcoma are more likely to develop pulmonary metastases. T1 means the tumor is 5 cm or less across, T2 means it is greater than 5 cm. Jun 1, 2009 · Following Up to My First Post on Spindle Cell Sarcoma I wanted to follow-up with an update on my Spindle Cell situation and to also thank you all for posting your reponses and support! Here's how it's played out In May, I had a Spindle Cell Tumor and a small margin of the surrounding tissue removed from my right groin area. Methods Patients receiving G 900 mg/m2 d 1, 8; D 75 mg/m2 d 8, every 21 days were eligible. The staging system divides sarcomas into 3 grades (1 to 3). [2] The genetic abnormalities in leiomyosarcoma are complex, and our current knowledge Dec 7, 2021 · Although there are some studies that challenged the concept of radioresistance of spindle cell carcinoma and reported similar responses and outcomes to the classical squamous cell carcinoma [10,11]. May 23, 2019 · Overall survival in a patient with spindle cell cancer depends on the age of the patient, the location of cancer, and staging at the time of diagnosis of cancer . Spindle cell sarcomas usually show positive immunoreactivity for vimentin, osteopontin, and MDM2 [12,13]. Sarcomas as a whole are characterised by an incidence of approximately 5 cases/100,000 thus matching the formal definition of a rare tumor 6. We retrospectively evaluated the activity of gemcitabine (G) plus docetaxel (D) in patients with relapsed high-grade osteosarcoma and high-grade spindle cell sarcoma of bone (HGS). A sample will be needed from the tumor and a cytologist will analyze the cells to determine if they are cancerous. In the ARST0332 (NCT00346164) study, patients with epithelioid sarcoma, clear cell sarcoma, or radiographically enlarged nodes underwent regional node sampling. Soft tissue sarcomas, including epithelioid sarcoma, are not common. Apr 9, 2018 · A biopsy confirmed Guin’s suspicions of a sarcoma. Sarcoma Patient Assistance. Pathological examination of the tumor revealed a neural-like spindle cell proliferation set in a fibrous background that was associated with an atypical lipomatous component, which usually included lipoblasts. Therefore, the prognosis and treatment of pulmonary SCC is unclear. Sarcoma is the general term for a broad group of cancers that begin in the bones and in the soft (also called connective) tissues (soft tissue sarcoma). Jun 11, 2024 · Follicular dendritic cell sarcoma (FDCS) is a rare low- to intermediate-grade sarcoma that most commonly presents as a slowly growing, painless mass with the histologic appearance of spindle-shaped cells in a whorled pattern. Herein, a case of 55-year-old woman who presented with a polypoid lesion at her tongue Spindle cell sarcoma is a rare disease with a poor prognosis. 1% at 1-year and 65% at 5-years. Spindle cell melanoma shares some common mutations with conventional melanomas and all patients should undergo genomic biomarker NGS testing in order to determine if there is a cancer driving mutation that can be treated with a precision cancer medicine. They’re long and slender, like a spindle. Mar 19, 2024 · Keywords: surveillance, epidemiology, and end results (SEER) database, nomogram, spindle cell melanoma, overall survival, SEER. It is commonly seen in older children and younger adults. (E) High-grade sarcoma showing highly atypical nuclei with 15 mitoses per 10 high power fields (HPF) including abnormal forms (H&E stain, x10). Soft tissue sarcoma forms in the tissues that connect, support and surround other body structures. Introduction. Go to: CASE REPORT. Giant cell carcinoma consists of large cells arranged in a pattern typical in sarcoma. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-specific mortality. The objective of this study was to establish nomograms to predict the OS and CSS prognosis of patients with SCS based on the Surveillance Oct 5, 2022 · The classification of soft tissue sarcomas includes various types (e. These cancers happen in the body's connective tissues. Sarcomatoid mesothelioma cells are simply mesothelioma cancer cells with a spindle shape. Presence of this tumor type in the tongue has rarely been reported. Later I was informed it was a spindle cell sarcoma tumor. Feb 28, 2022 · The variants included under embryonal RMS include sarcoma botryoides, anaplastic type and spindle cell type. Primary spindle cell sarcoma of the left atrium is a rare tumour. , well-differentiated, dedifferentiated, myxoid and pleomorphic liposarcoma; embryonal, alveolar, pleomorphic, and spindle cell What is spindle cell sarcoma? Spindle cell sarcoma is a rare malignant (cancerous) tumour which can develop in the bone or soft tissue. Hi There, I can try to help. Though the morphology of DCS was highly variable, the immunophenotype was predominant myogenic phenotype. Hello all, Im 29 and had a high grade large tumor (11cm) in my right thigh that was synovial sarcoma. The objective of this study was to establish Nov 11, 2017 · Moreover, other spindle-type tumours such as the monophasic fibrous synovial sarcoma, malignant peripheral nerve sheath tumour (MPNST), solitary fibrous tumour (SFT), aggressive fibromatosis as well as spindle-cell types of angiosarcoma, rhabdomyosarcoma, leiomyosarcoma and epitheloid sarcoma should be distinguished from fibrosarcoma [6, 5, 11 Jun 9, 2020 · The exact cause of spindle cell melanoma is unknown. Epithelioid sarcoma. Mar 29, 2015 · Never the less surgery has been shown to prolong the survival and improve the quality of life . It can arise in any part of the body but is most common in the limbs (arms and legs). Jun 20, 2018 · Histological analysis and immunohistochemical staining of the lung biopsy (A) Hemotoxylin and eosin staining showed that the tumor cells are predominantly composed of spindle cells with increased mitotic activity and areas of necrosis; (B) Tumor cells were weakly positive for P63 staining; (C) Vimentin showed strongly positive tumor cells; (D) Cytokeratin-Oscar showed tumor cells to be Dec 27, 2023 · Spindle cell sarcoma (SCS) is rare in clinical practice. The lump may or may Mar 22, 2018 · Spindle cell neoplasm are diverse in nature by means of clinicopathologic and tumor biological heterogeneity 1. GISTs happen most often in the stomach and small intestine. However, the weak cytokeratin expression of CK14 and P63 as seen in this case favored the diagnosis of metaplastic carcinoma—spindle cell type over spindle cell sarcoma. Occasional cases have an inflammatory Dec 11, 2020 · Among the subsets of undifferentiated soft tissue sarcomas is the spindle cell variant, which our case resembled histologically. Dermatofibrosarcoma protuberans. 2%–0. While this rare malignancy can affect anyone, it is most frequently diagnosed in adults 40 and older. In one third of synovial sarcomas, areas of calcifications and/or ossification can be Jan 12, 2022 · The maximum survival rate is five years for people with advanced stage spindle cell sarcoma. The five-year metastasis-free survival rate is 40% to 60%. 2;q11. The survival rate for spindle cell carcinoma is 39%, compared to the squamous cell skin cancer survival rate, which is 99% when caught early. 5 cases/million/year in Sweden (), 14. Spindle cell sarcomas are also known as soft tissue sarcomas (STS) and in general, this term acts as an umbrella for a variety of tumors including (fibrosarcoma-connective tissue, chondrosarcoma-cartilage, liposarcoma-fat tissue, hemangiosarcoma-blood vessel cells, nerve sheath tumor, hemangiopericytoma-cells supporting blood vessels, malignant fibrous histiocytoma). Many survivors have regular screening exams to check for a return of the disease. It is important that an accurate diagnosis is made, confirming the type of spindle cell sarcoma that is presenting, to allow the most appropriate treatment plan to be put into place. 1 The incidence of spindle cell carcinoma on the oral cavity is very rare and accounts for less than 1% of all oral cavity tumours. Feb 20, 2011 · Spindle cell carcinoma is a rare biphasic tumor consisting of epithelial and mesenchymal components. It is a type of connective tissue tumor and generally begins in layers of connective tissue such as that under the skin, between May 19, 2021 · It presents as one of three variants: monophasic, biphasic or poorly differentiated. “Spindle cell sarcoma is a soft-tissue tumor that can start in the bone, often in the arms, legs or pelvis,” said Siegel, a professor in the Department of Orthopedic Surgery in the School of Medicine. Spindle cell carcinoma (SpCC) is a rare tumor, which occurs in upper respiratory tract, mainly in larynx. LGMS is characterized by a low malignancy potential, tendency for local recurrence, and low likelihood of distant metastases. Aug 29, 2022 · The spindle cell subtype resembles a low-grade sarcoma, which is the most common histologic subtype found in western patients and is reported to be associated with poor prognosis [8,9]. Oct 7, 2021 · Although the treatment of metastatic alveolar soft part sarcoma with antiangiogenic agents such as apatinib, bevacizumab, and sunitinib has not effectively prevented recurrence, antibodies targeting programmed cell death 1 and its ligand may improve survival rates in these patients. Adjuvant chemo for Synovial Sarcoma. Jan 23, 2015 · Myxoid tumors can be benign (including locally aggressive tumors) or frankly malignant. I am supposed to be undegoing chemo and radiation to shrink it before surgery. Median time from diagnosis of sarcoma to diagnosis of metastases was 12 months (range: 0–155 months). It makes up only 2-5% of all types of bone cancer and typically presents in people over 40 years of age. No individual conflict of interest exists in the study. [1] Originating from either smooth muscle cells or their mesenchymal cell precursors, leiomyosarcoma primarily occurs in the retroperitoneum, uterus, and extremities, in descending order of frequency. May 6, 2023 · Synovial sarcoma (SS) is a mesenchymal tumor with partial epithelial differentiation. Although the exact incidence of GISTs in the world is hard to determine since the entity was not uniformly defined until the late 1990s, a few estimates and studies indicate the incidences of approximately 14. A cell's DNA contains the instructions that tell a cell what to do. At 6 and 12 months, the local control was 89%. Spindle cell sarcoma is a type of connective tissue cancer. It tends to have a favorable prognosis, with lymph node involvement relatively uncommon, provided it is detected early and treated appropriately [ 1 ]. Sarcomas are accounting for 95% of these malign tumors and they show different histologies. Sarcoma Symptoms. There are only 13 reported cases in literature, only three of which Aug 7, 2024 · This means sarcomatoid cells have a spindle shape akin to an elongated oval with narrow, pointy ends. Survival rates for soft tissue sarcoma in children and adolescents vary depending on the soft tissue sarcoma type. g. Therefore, we aimed to characterize the clinicopathological characteristics A spindle cell sarcoma is a soft tissue tumor that originates in a bone. Spindle cell sarcoma is a rare, rapidly growing connective tissue tumor that has a propensity for local recurrence and frequently metastasizes to the lungs. Spindle cell tumor and spindle cell sarcoma are descriptive names used when tumor cells look long and narrow under the microscope. The spindle cell or sarcomatoid component of this tumor can mimic numerous other reactive, benign, and malignant lesions (Table 1 ). Apr 6, 2012 · Epidemiology. In the monophasic variant, the tissue is comprised entirely of spindle-cells whereas in biphasic synovial sarcoma, there are epithelial and spindle-cell components present . Dec 7, 2021 · Background Low-grade myofibroblastic sarcoma (LGMS) is a poorly studied, rare, soft tissue sarcoma. He refered me to a surgical oncologist and told me that the outlook should be pretty good since the tumore was so small. These statistics are for people diagnosed between 2014 and 2016 for all stages of bone sarcoma in England: almost 85 out of 100 people (almost 85%) survive their cancer for 1 year or more Sep 4, 2018 · Sclerosing and spindle cell rhabdomyosarcoma is a rare histologic subtype, designated in the latest WHO classification as a stand-alone pathologic entity. 2) is a pathognomonic feature of synovial sarcoma. 4% of all primary lung malignancies. Tell us about the types of synovial sarcoma and the differences between them. The earliest reports suggested it was the The grade (G) of the cancer: How much do the sarcoma cells look like normal cells? Grade. Ewing sarcoma of soft tissue survival Spindel Cell Sarcoma 4 years ago my wife Mary had a lumpectomy and it was diagnosed as Spindle Cell Sarcoma. Case presentation We report a case of DCS with neurogenic differentiation proved by immunohistochemical staining my mom has been battling with spindle cell sarcoma stage 4 in ribs, spine, hips, femur, adrenal gland and has now spread to lungs, liver and lymph nodes. Learn where sarcomatoid carcinoma develops, the types, risk factors, symptoms, diagnosis, and treatment. The objective of this study was to establish nomograms to predict the OS and CSS prognosis of patients with SCS based on the Surveillance, Epidemiology, and End Results (SEER) database. Sarcoma Networking meets monthly on every 4th Wednesday from 6:30pm to 8:30pm at Gilda’s Club Kentuckiana in Louisville, Kentucky. The letter “a” (T1a, T2a) indicates that the tumor is near the surface of the body, while “b” (T1b, T2b) indicates it is deeper in On univariate analysis, when the expression of p27(Kip1) and cyclin E was analyzed together, patients with spindle-cell sarcoma exhibiting low expression of p27(Kip1) and high expression of cyclin E showed lower distant-metastasis-free survival (DMFS) and overall survival (OS) than those with other combinations of the two parameters (both P < 0 Feb 2, 2017 · The SEER database tracks 5-year relative survival rates for soft tissue sarcoma in the United States, based on how far the cancer has spread. The typical cases of Spindle Cell Sarcoma are developed after 40 years of age, but it can occur in younger aged people and even some animals like cats and dogs has also probability to develop spindle cell sarcoma. The most common histology was spindle cell sarcoma or leiomyosarcoma. Synovial sarcoma, malignant peripheral nerve sheath tumor, fibrosarcoma, inflammatory myofibroblastic tumor, low-grade myofibrosarcoma, leiomyosarcoma, spindle cell rhabdomyosarcoma, and endothelial neoplasms are discussed in terms of an overview of the tumor, microscopic and gross features, diagnostic techniques, genetic Key findings: Net survival for all soft tissue sarcomas was 85. There is a great facebook page called Undifferentiated Pleomorphic and Spindle Cell Sarcomas that might be of help to you. Methods: We performed a retrospective analysis using the SEER database from 1975-2016 to study the demographics, treatment modalities and outcomes for patients Sep 24, 2021 · Recently, Sim et al. Spindle Nov 3, 2020 · Rarity. demonstrated excellent durable local control when treating 24 patients with 58 discrete lesions. That means that 5 to 6 out of 10 people with synovial sarcoma are still alive five years after their diagnosis. Spindle cell carcinoma (SpCC) of the head and neck is a rare, biphasic neoplasm first described by Virchow in 1865 []. Spindle cell melanoma (SCM) is a rare subtype of malignant melanoma composed of spindled neoplastic cells arranged in sheets and fascicles (). This may shrink the tumor enough to remove it entirely with surgery. Herein, we present a rare case of primary spindle cell sarcoma of the breast. Aug 25, 2022 · Surgery is the main treatment for spindle cell carcinoma. It is an aggressive and poorly differentiated variant that predominantly occurs in the larynx. 1, 2 Treatment consists of surgical excision, 2 radiotherapy, and chemotherapy. Mar 28, 2023 · Nuclear pleomorphism is often striking, but a subset of tumors exhibits uniform cytological features. She just had a full mastectomy as she had a re-occurrence in the same breast with a tumor that grew to 3 cm in less then 6 months. The cells can invade and destroy nearby healthy Oct 27, 2022 · Spindle cell carcinoma is an aggressive, uncommon sarcoma-like form of cancer. Information is presented on the pathology of spindle cell sarcomas. The changes tell the cell to multiply rapidly, creating a mass of abnormal cells (tumor). 55 mm in diameter and 0. It is a mixed tumor, composed of both malignant epithelial and mesenchymal elements. The typical symptom of sarcomas is a slow-growing, painless mass. The tumors generally begin in layers of connective tissue, as found under the skin, between muscles, and surrounding organs, and will generally start as a small, inflamed lump, which grows in size. I am 18 years old and about a week ago I got what I had been told was a small cyst removed from my left shoulder. It can start in the bone, often in the arms, legs, and pelvis, and usually occurs in people over 40. Three genomic groups have been defined Among the types reported are fibrosarcoma, follicular dendritic cell sarcoma, desmoplastic nested single-cell tumor, malignant fibrous histiocytoma, hemangiopericytoma, osteosarcoma, malignant schwannoma, and dedifferentiated liposarcoma (Choi et al, 2010; Hill et al, 2005; Li et al, 2008; Kim et al, 1987; Lederman et al, 1987). Anderson Cancer Center. The grade is partly used to determine the stage of a sarcoma. If the tumor is not in a limb, (for example, it's in the head, neck, or abdomen), it can be harder to take out the entire tumor and enough normal tissue around it. There are only 13 reported cases in literature, only three of which had a survival of more than 11 months. The presence of t(X;18)(p11. Oct 13, 2020 · In 1968, Farrow and colleagues 29 coined the term “sarcomatoid renal cell carcinoma” to describe a renal malignancy closely resembling a sarcoma with pleomorphic spindle-cell and giant-cell Spindle Cell Carcinoma (Sarcomatoid Carcinoma, Carcinosarcoma) Fig. There is a male preponderance with a male-to-female ratio of 6:1. The first symptom is usually swelling or a lump under the skin. The symptoms of spindle cell sarcoma can be non-specific and may be different depending on the exact location of the tumour and the tumour type. Here, we report a case of a 37-year-old man with spindle cell sarcoma of the paraspinal muscles, which recurred locally after surgery. Mar 26, 2020 · The most common histologic types of radiation-associated sarcomas are undifferentiated pleomorphic/spindle cell sarcoma and angiosarcoma, which together account for approximately 80% of all cases. Mar 27, 2024 · Spindle cell carcinoma (SCC), also called sarcomatoid carcinoma or carcinosarcoma, represents a rare variant of squamous cell carcinoma that may involve multiple organs, including the larynx. Citation: Lau WC, Huang L, Zheng X, Ming W-k, Leong NC, Tak Wong Y, Yin Z, Yu H, Lyu J and Deng L (2024) Prognostic nomograms for predicting long‐term overall survival in spindle cell melanoma: a population‐based Within days Dr. At the end of 2015 my dad who is only 54 years old was diagnosed with a rare form of kidney cancer called Spindle Cell Sarcoma. Tenosynovial giant cell tumors (also called nodular tenosynovitis): benign tumors of joint tissue; Spindle cell tumors. Type of Sarcoma; Year of Diagnosis; Area of body affected Overall, experts estimate about 65% of adults with soft tissue sarcoma are alive five years after diagnosis. It is especially uncommon in patients with no prior history of radiation therapy to the breast. Cutaneous clear-cell sarcoma tends to show uniform patterns of spindle-cell fascicles (bundles) under microscopy, which are present throughout an entire tumour Nov 20, 2018 · Univariate Kaplan–Meier and Cox regression analyses of five-year sarcoma specific and overall survival according to different characteristics of all spindle cell non-osteogenic bone sarcoma. Aug 23, 2016 · Synovial sarcoma may also occur in the lungs, so see your doctor if you notice shortness of breath. Feb 28, 2023 · Spindle cell sarcoma is very rare, comprising as little as 2% of all primary bone cancer cases. Nodal metastases were identified in 20 patients (3. Spindle cell sarcoma can develop for a variety of reasons . 50% of people diagnosed with spindle cell sarcoma in England survive their disease for five years or more (2013-2017). Spindle cell sarcoma is a soft tissue tumor usually found in the arm or leg bones, or in the pelvis. Once soft tissue sarcoma has spread to other parts of the body, the 5-year survival rate is about 18%. Historically most spindle cell RPMBS were diagnosed as MFH , and treated according to osteosarcoma-like chemotherapy regimens (adriamycin, cisplatin, ifosfamide, and methotrexate), with a lower rate of good histologic response to induction chemotherapy but survival comparable to that of high grade osteosarcoma. A GIST is a growth of cells that's thought to form from a special type of nerve cells. Where the spindle cell component was positive, the intensity and distribution was lower than that for squamous component. Discuss what to expect with your provider. Oct 23, 2020 · 6. Medically Reviewed I was just diagnosed with a Grade 3 tumor/stage 3 Spindle cell cancer in my right calf The tumor is 10X10X20 centimeters and I'm currently about 10 radiation treatments in an expected to do 28 total After radiation I'm supposed to wait 4-6 weeks of rest followed by surgery There hasn't been any talk of treatment after this Jan 21, 2022 · Spindle cell sarcoma is one of the rare varieties of undifferentiated soft-tissue sarcomas [ 5 ]. 7 in Taiwan (), 12. In June of 2008 my boyfriend started to complain of stomach pain and he could feel a bump on his right side just under his ribs- again after many tests they also found a spot on his heart valuve he was diagnosed with stage 4 spindle cell sarcoma they went in and replaced the valuve and the bump from his side was football size tumor Dec 20, 2021 · 1. Sarcoma Networking — Moderated by a counselor, this support group is for sarcoma patients and survivors. Jorge Casas-Ganem, a brilliant orthopedic surgeon at Dallas Sarcoma Associates, removed a large, cantaloupe sized tumor. Type of Sarcoma: Spindle Cell Synovial Sarcoma Date of Diagnosis: 2013 Location: leg, lung. As indicated by previous reports, epithelioid sarcoma and clear cell sarcoma were the two NRSTS included in this study. What is spindle cell mesothelioma? Spindle cell mesothelioma is an unofficial term for sarcomatoid mesothelioma. 2% at 5-years. Here we reported a long-term survival of a patient with pulmonary SCC who underwent treatment with A friend of mine was diagnosed with spindle cell sarcoma in the lungs 2 years ago. There are two major types: monophasic, which is made up of only spindle cells, and biphasic, which is made up of both spindle cells and epithelial cells. The simplistic step is to classify them on a simple descriptive basis as spindle cell sarcomas, myxoid sarcomas, pleomorphic sarcomas, and small round cell sarcomas . They usually form in the upper part of your lungs. The squamous subtype was found to be more common in the Asian population [ 4 , 8 ]. Apr 20, 2016 · Background Few new compounds are available for relapsed osteosarcoma. As May 28, 2008 · The most common spindle cell lesion presenting along the UADT mucosa is spindle cell carcinoma (SpCC), which has many unique and challenging clinical and pathologic features. D. 2 in Northern Italy (), 13. It works best to attach a jpeg format of the photo(s) to your email. A large retrospective series from Memorial Sloan Kettering Cancer Center (MSKCC), including 3829 soft tissue sarcoma (STS) patients over a 17-year period, reported only 40 cases with brain metastases [], corresponding to an incidence <1%. Gastrointestinal stromal tumor (GIST). “Soft-tissue sarcomas are rare in adults, accounting for less than 1 percent of all Dec 30, 2023 · It's not clear what causes undifferentiated pleomorphic sarcoma. I know its not easy finding others, especially when the site does't let you know if anyone has responded. Less common subtypes include MPNST, leiomyosarcoma, and osteosarcoma (either arising in soft tissue or bone). The tumor can arise anywhere within the upper aerodigestive tract, with a predilection for the larynx May 23, 2023 · Spindle cell sarcoma is an aggressive cancer, but there are treatments that can slow its growth and, in some cases, cure it completely. Most primary cardiac tumors are benign and around one quarter is malign. Aug 15, 2024 · Survival for all types and stages of soft tissue sarcomas. 3 months after her surgery she had her first CT scan and the result shows that there are new asking for treament options spindle cell sarcoma Best wishes and good luck to everyone here. Due to the rarity of diagnosis, there is a dearth of information about the epidemiology and overall survival for these patients. Dec 27, 2023 · Spindle cell sarcoma (SCS) is rare in clinical practice. Diagnosis of spindle leiomyosarcomas requires the presence of two of three features: tumor cell necrosis, marked cytological atypia, and ⩾4 mitoses/mm 2 (equating to ⩾10 mitoses/10 HPF of 0. From skeletal muscle, adipose tissue, blood, and lymphatics to connective tissue and peripheral nerves, these neoplasms can span a range of clinical presentations from benign lipomas to aggressive metastatic May 20, 2014 · Most frequent histologies were leiomyosarcoma (n=5), undifferentiated pleomorphic/spindle cell sarcoma (n=5), alveolar soft part sarcoma (ASPS) (n=5 from a group of 14 patients), Ewing sarcoma (n=3) and liposarcoma (n=3). All the best on your journey I pray for a treatment that works for you. In this instance, there Apr 27, 2023 · The type of cell with DNA changes is what determines the type of soft tissue sarcoma. Several hundred cases have been reported since it was first described in 1986 . Sep 8, 2018 · Spindle cell carcinoma (SCC) is a rare pulmonary malignancy, accounting for only 0. Spindle cell carcinoma is more common in men than in women, with an approximate ratio of 2. 3 In a series of 242 patients, those with tenosynovial sarcoma also had an increased incidence of pulmonary metastases. (1-5) Dec 28, 2022 · Sarcoma is a type of cancer that can occur in various locations in your body. Variable positivity may be Oct 12, 2022 · For cats, there is less data about specific histological subtypes and their relative frequencies, but the STS group would be likely to include NST, fibrosarcoma, myxosarcoma, leiomyosarcoma, liposarcoma, rhabdomyosarcoma, perivascular wall tumours and unspecified spindle cell tumours/sarcoma arising in the dermis or subcutis, regardless of Pulmonary spindle-cell carcinoma (SpCC) is a highly malignant variant of SC, representing <0. These special nerve cells are in the walls of the digestive organs. 8%), and all Nov 30, 2021 · Spindle cell carcinoma, also known as sarcomatoid carcinoma, is an exceedingly rare variant of SCC with a unique clinicopathological profile. Spindle cell tumor is not a specific diagnosis or a specific type of cancer. Other lineage markers were consistently negative. The SEER database, however, does not group cancers by AJCC TNM stages (stage 1, stage 2, stage 3, etc. Jan 10, 2019 · Spindle cell carcinoma is a rare breast tumor, with an estimated yearly incidence <0. 10. It appeared the cancer was finished for almost two years; however, my second anniversary showed a 5mm spot on my right lung. The differentiation of cutaneous clear cell sarcoma from spindle cell melanoma is largely histological, as both may stain positively for the same indicators: S100, HMB-45, and Melan-A. survival and cancer‑specic survival in spindle cell sarcoma patients Hao Pan1,2* Spindle cell sarcoma (SCS) is rare in clinical practice. There are no UK-wide statistics available for soft tissue sarcoma survival by stage. Although no optimal treatment method has been established, in the present case, incomplete surgical resection and postoperative carbon-ion radiotherapy were performed, yielding a relatively long survival period. Pathologists often use the term spindle-cell neoplasm when describing a small tissue sample, such as a biopsy. 69. 5 in Norway (). Learn more about the risk to you and your family on our genetic testing page. A 501(c)(3) non-profit organization focused on easing the financial burden of sarcoma patients at M. It is sort of wrapped around the bone and too big to remove. The 5-year survival rate for cancer that has reached nearby organs or lymph nodes is about 50%. Significant overall survival (OS) and disease specific survival (DSS) were found differentiated in gender, age, marital status, primary tumor location, AJCC stage, T stage, N stage, M stage, pathologic grade and treatment modality. Apr 27, 2023 · Epithelioid sarcoma is a type of cancer called a soft tissue sarcoma. Synovial sarcoma usually affects young adults. The surgery left a major wound and void in my leg. He underwent aggressive chemotherapy and ended up having surgery last spring Apr 10, 2023 · The undifferentiated pleomorphic sarcoma (UPS) —formerly known as malignant fibrous histiocytoma, is a high-grade aggressive soft-tissue sarcoma (STS). Distant brain control and overall survival remained poor at 34% and 38%, respectively, at 12 months . Feb 20, 2020 · The main differential diagnoses for cutaneous spindle cell malignancies are spindle cell melanoma, atypical fibroxanthoma, pleomorphic dermal sarcoma, angiosarcoma, leiomyosarcoma and carcinosarcoma (Table 1) [17,18]. Overall, the 5-year survival rate for soft tissue sarcomas is about 65%. ywknkzf wovtm aqklzer dmhwn awbsc ysw bkh blbynu dzi omaq